The Effect of Aerobic Exercise on Leptin, Fasting Blood Sugar, Blood Insulin Levels and Insulin Resistant Factor in Patients with Type II Diabetes Mellitus

Background: Diabetes Mellitus is a heterogeneous group of different metabolic disorders that are characterized by chronic increase of blood glucose, cardiovascular diseases, and proteins, lipids and carbohydrate metabolism disorder. Leptin, that is a marker of fat mass in the body, has an important role in the body total metabolism and glucose homeostasis. Aim: To investigate the effect of 12 weeks of aerobic exercise on leptin and glucose homeostasis in patients with type II diabetes. Method: In this quasi-experimental study, 40 men with type П diabetes referring to Mashhad Parsian Clinic were allocated into two groups: aerobic (20 participants) and control (20 participants). Aerobic group performed selected exercises in 12 weeks (three 40 min sessions per week with %60-%70 heart rate reserves). The levels of leptin, fasting glucose, insulin and insulin resistant factor were measured. Data were analyzed with SPSS version 11.5 using t student and Paired t test, and also Mann-Whitney, and Wilcoxon tests. The level of significance was considered to be 95% (p